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MDM2 Polyclonal Antibody

No Catalog : BZ-0800350-AP

Reactivity : Human,Mouse,Rat

Source : Rabbit

Type : Polyclonal

Application : IHC-p WB ELISA IF

MDM2 encodes a nuclear-localized E3 ubiquitin ligase. The MDM2 proto-oncogene can promote tumor formation by targeting tumorsuppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2HostRabbit
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