TGFBR2 encodes a member of the Ser/Thr protein kinase family and the TGFB receptor The TGF-beta receptor type-2 is a transmembrane protein that has a protein kinase domain, forms heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

TGFBR2; TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II