VDR encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor forthe secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptionalregulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors.Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolismthough the receptor regulates a variety of other metabolic such as those involved in the immuneresponse and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. Asingle nucleotide polymorphism in the initiation codon results in an alternate translation start site threecodons downstream. Alternative splicing results in multiple transcript variants encoding different proteins

VDR; NR1I1; Vitamin D3 receptor; VDR; 1; 25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1