The protein encoded by NBR1 (NBR1, autophagy cargo receptor) was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by intracellular inclusions with ubiquitylated autophagic substrates. NBR1 is located on a region of chromosome 17q21. that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of NBR1 results in multiple transcript variants.

Next to BRCA1 gene 1 protein; Cell migration-inducing gene 19 protein;Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B.