The protein encoded by EDNRB (endothelin receptor type B) is a G protein-coupled receptor activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: eT1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor B gene. Alternatively spliced transcript variants encoding different isoforms have been found for EDNRB.

Endothelin B receptor (ET-B) (ET-BR) (Endothelin receptornon-selective type)