PROM1 encodes a pentaspan transmembrane glycoprotein. Prominin-1 localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in stem cell properties by suppressing differentiation. Mutations in this gene have been shown to in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with types of cancer. This gene is expressed from at least five alternative promoters that are expressed a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.

PROM1; Prominin-1; Antigen AC133; Prominin-like protein 1; CD133