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Bax mouse Monoclonal Antibody(6F11)

No Catalog : BZ-080100-AM

Reactivity : Human,Rat,Mouse,Chicken

Source : Mouse

Type : Monoclonal

Application : IHC-p WB IF

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which playsa pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthycells, butaccumulates on the outer mitochondrial membrane upon apoptosis induction (PMID:9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to themitochondria and permeabilization of the outer mitochondrial membrane, which leads to therelease of cytochrome c from mitochondria (PMID: 21763611). The expression of BAX isupregulated by the tumor suppressor protein p53, and BAX has been shown to be involved inp53-mediated apoptosis.

Apoptosis regulator BAX, BAX
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